ESR EVIDENCE FOR THE OXIDATIVE CLEAVAGE OF GENTISIC ACID IN BASIC AQUEOUS-SOLUTION

被引：2
|
作者：
CAPELLE, S [1 ]
PAILLAT, C [1 ]
COTELLE, P [1 ]
PLANCKAERT, B [1 ]
CATTEAU, JP [1 ]
机构：
[1] UST LILLE,CHIM PHYS ORGAN LAB,CNRS,URA 351,VILLENEUVE DASCQ,FRANCE
来源：
REDOX REPORT | 1995年 / 1卷 / 03期
关键词：
D O I：
10.1080/13510002.1995.11746988
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The oxidative cleavage of 2,5-dihydroxybenzoic acid (gentisic acid), presumably into maleylpyruvate in basic aqueous solution has been shown by ESR spectra of semiquinonic radicals bearing a methylenic group. One of these radicals has been unambiguously attributed to 2,4,5-trihydroxyphenylacetic acid semiquinonic radical. The formation of an hydroxylated homogentisic acid from gentisic acid (a metabolite of aspirin) is of particular importance in the treatment of alkaptonuria and related inflammatory arthritis.
引用
收藏
页码：219 / 223
页数：5
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