OVEREXPRESSION OF THE MET HGF RECEPTOR IN OVARIAN-CANCER

被引:188
作者
DIRENZO, MF
OLIVERO, M
KATSAROS, D
CREPALDI, T
GAGLIA, P
ZOLA, P
SISMONDI, P
COMOGLIO, PM
机构
[1] S GIOVANNI GEN HOSP,DEPT ONCOL,TURIN,ITALY
[2] UNIV TURIN,SCH MED,DEPT GYNECOL ONCOL,TURIN,ITALY
关键词
D O I
10.1002/ijc.2910580507
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The MET oncogene encodes the receptor for Hepatocyte Growth Factor/Scatter Factor, a unique growth factor that induces not only proliferation of epithelial cells, but also cell motility and invasiveness. DNA level and expression of the Met/HGF receptor gene were examined with Southern- and Western-blot analyses, respectively, in human ovary, benign ovarian tumors and epithelial ovarian carcinomas. The Met/ HGF receptor was detectable in the surface epithelium of normal ovary. The level of expression was unchanged in benign ovarian tumors of various origins. Fourteen out of 67 malignant carcinomas (20%) showed a 3- to 10-fold increase in expression. in 5 additional cases the Met/HGF protein was overexpressed over 50-fold. This represents a total of 28% of cases. Overexpression was not associated with MET gene amplification. Overexpressing tumors belonged to different histotypic variants, but showed a well-differentiated phenotype. Clinically, overexpression was associated with disease at any pathologic stage, but was significantly correlated with premenopausal status of patients. These data suggest that expression of the Met/HGF receptor may add a selective growth advantage to a narrow subset of differentiated ovarian cancers in premenopausal patients. (C) 1994 Wiley-Liss, Inc.
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页码:658 / 662
页数:5
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