EPIGENETIC EFFECTS IN EUKARYOTIC GENE-EXPRESSION

被引：41
作者：
BESTOR, TH
CHANDLER, VL
FEINBERG, AP
机构：
[1] UNIV OREGON,INST MOLEC BIOL,EUGENE,OR
[2] JOHNS HOPKINS UNIV,SCH MED,DEPT MED,BALTIMORE,MD
[3] JOHNS HOPKINS UNIV,SCH MED,DEPT MOLEC BIOL & GENET,BALTIMORE,MD
来源：
DEVELOPMENTAL GENETICS | 1994年 / 15卷 / 06期
关键词：
EPIGENETIC PHENOMENA; CHROMATIN STRUCTURE; EUKARYOTES;
D O I：
10.1002/dvg.1020150603
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In the broadest terms, epigenetic phenomena in eukaryotes depend on the interaction of alleles or repeated sequences or on the mitotic inheritance of chromatin states or methylation patterns. One of the most exciting aspects of the study of epigenetic phenomena is the insight that can be gained into the structure and assembly of higher-order chromatin structures, an important subject that has proved refractory to current biochemical methodologies. Rapid progress in the study of gene inactivation in fungi, plants, and invertebrates will provide new hypotheses to be tested in mammals. (C) 1994 Wiiey-Liss, Inc.
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页码：458 / 462
页数：5
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