MULTIPLE GLYCOSPHINGOLIPIDS DETERMINE THE TISSUE TROPISM OF PARVOVIRUS B19

被引:107
作者
COOLING, LLW
KOERNER, TAW
NAIDES, SJ
机构
[1] UNIV IOWA, DEPT INTERNAL MED, DIV RHEUMATOL, IOWA CITY, IA 52242 USA
[2] UNIV IOWA, DEPT BIOCHEM, IOWA CITY, IA 52242 USA
[3] UNIV IOWA, DEPT PATHOL, IOWA CITY, IA 52242 USA
[4] VET ADM MED CTR, IOWA CITY, IA USA
关键词
D O I
10.1093/infdis/172.5.1198
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Infection with human parvovirus B19, the etiologic agent of fifth disease, is associated with numerous hematologic and nonhematologic complications. Recently, the receptor for parvovirus B19 was reported to be globoside (Gb4), a neutral glycosphingolipid (GSL) of red cell membranes. To ascertain if tissue Gb4 expression correlates with B19-associated disease, neutral GSLs from 16 human tissues were isolated and analyzed using high-performance thin-layer chromatography and immunostaining with anti-Gb4 monoclonal antibodies or B19 empty capsids. Gb4 was identified as a major neutral GSL in 11 tissues, especially in those of mesodermal origin. In addition to recognizing Gb4, B19 capsid bound to several tissue-specific GSLs, including two complex globe series GSLs (SSEA-S, SSEA-4) and paragloboside (neolactotetraglycosylceramide), as was demonstrated in red cell, granulocyte, kidney, liver, and bowel tissue. There was good correlation between tissue-neutral GSL expression, B19 capsid binding, and the tissue tropism observed clinically in B19 parvovirus-associated disease.
引用
收藏
页码:1198 / 1205
页数:8
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