FETAL AND MATERNAL LEVELS OF CORTICOSTERONE AND ACTH AFTER PHARMACOLOGICAL ADRENALECTOMY

被引：25

作者：

BARAM, TZ

SCHULTZ, L

机构：

[1] Dept. Neurology, University of Southern California

来源：

LIFE SCIENCES | 1990年 / 47卷 / 06期

关键词：

D O I：

10.1016/0024-3205(90)90607-S

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A paradigm of pharmacological adrenalectomy of pregnant rats and fetuses in utero is described. A regimen of twice daily metyrapone injections (10mg/100gm body weight), results in marked depression of serum corticosterone in pregnant and in fetal rats without surgical trauma and stress. The technique should be useful in a wide variety of studies involving the developing brain-adrenal axis. © 1990.

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页码：485 / 489

页数：5

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