Transcatheter Arterial Chemoembolization Is a Feasible Palliative Locoregional Therapy for Breast Cancer Liver Metastases

被引：21

作者：

Cho, Sung W. ^{[1
]}

Kitisin, Krit ^{[2
]}

Buck, David ^{[3
]}

Steel, Jennifer ^{[1
,4
]}

Brufsky, Adam ^{[5
]}

Gillespie, Roberta ^{[1
]}

Tsung, Allan ^{[1
]}

Marsh, James W. ^{[1
]}

Geller, David A. ^{[1
]}

Gamblin, T. Clark ^{[1
,2
,6
]}

机构：

[1] Univ Pittsburgh, Sch Med, UPMC Liver Canc Ctr, Div Transplantat,Dept Surg, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Sch Med, UPMC Liver Canc Ctr, Div Surg Oncol,Dept Surg, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Sch Med, UPMC Liver Canc Ctr, Dept Radiol, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Sch Med, UPMC Liver Canc Ctr, Dept Psychiat, Pittsburgh, PA 15213 USA

[5] Univ Pittsburgh, Sch Med, UPMC Liver Canc Ctr, Dept Med, Pittsburgh, PA 15213 USA

[6] Med Coll Wisconsin, Div Surg Oncol, Milwaukee, WI 53226 USA

来源：

INTERNATIONAL JOURNAL OF SURGICAL ONCOLOGY | 2010年 / 2010卷

关键词：

D O I：

10.1155/2010/251621

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background. Liver metastases are common in advanced breast cancer. We sought to evaluate the role of transcatheter arterial chemoembolization (TACE) in breast cancer patients with hepatic metastases. Methods. A retrospective review of ten patients with breast cancer who were treated with TACE for unresectable liver metastases (1998-2008). Results. All patients, median age 46.5, had received prior systemic chemotherapies. Adriamycin was administered for 6, cisplatin/gemcitabine for 2, cisplatin for one and oxaliplatin for one patient. Median number of TACE cycles was 4. Kaplan Meier survival analysis showed an increase in median survival for patients who responded to treatment when compared to those who did not respond (24 vs 7 months, P = .02). Conclusions. This is one of the largest series of breast cancer patients with liver metastases treated with TACE. It suggests that TACE is a feasible palliative option and warrants further investigations.

引用

页数：8

共 23 条

[1] Is liver resection justified for patients with hepatic metastases from breast cancer? [J].

Adam, Rene ;

Aloia, Thomas ;

Krissat, Jinane ;

Bralet, Marie-Pierre ;

Paule, Bernard ;

Giacchetti, Sylvie ;

Delvart, Valerie ;

Azoulay, Daniel ;

Bismuth, Henri ;

Castaing, Denis .

ANNALS OF SURGERY, 2006, 244 (06) :897-908

[2] Prognostic significance of liver metastases as first site of generalisation in patients with breast cancer - A retrospective analysis [J].

Baur, M ;

Schlappack, O ;

Havelec, L ;

Wrba, F ;

Dittrich, C .

ACTA MEDICA AUSTRIACA, 2001, 28 (05) :135-140

[3] An attempt to clarify indications for hepatectomy for liver metastases from breast cancer [J].

Elias, D ;

Maisonnette, F ;

Druet-Cabanac, M ;

Ouellet, JF ;

Guinebretiere, JM ;

Spielmann, M ;

Delaloge, S .

AMERICAN JOURNAL OF SURGERY, 2003, 185 (02) :158-164

[4]

Giroux MF, 2004, J VASC INTERV RADIOL, V15, P289

[5] Hepatic artery embolization and chemoembolization for treatment of patients with metastatic carcinoid tumors: The MD Anderson experience [J].

Gupta, S ;

Yao, JC ;

Ahrar, K ;

Wallace, MJ ;

Morello, FA ;

Madoff, DC ;

Murthy, R ;

Hicks, ME ;

Ajani, JA .

CANCER JOURNAL, 2003, 9 (04) :261-267

[6] BREAST LIVER METASTASES - INCIDENCE, DIAGNOSIS AND OUTCOME [J].

HOE, AL ;

ROYLE, GT ;

TAYLOR, I .

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 1991, 84 (12) :714-716

[7]

HUNT TM, 1990, BRIT J SURG, V77, P779

[8]

JARDINES L, 1993, SEMIN ONCOL, V20, P538

[9] Radiofrequency ablation (RFA) as a cytoreductive strategy for hepatic metastasis from breast cancer [J].

Lawes, D. ;

Chopada, A. ;

Gillams, A. ;

Lees, W. ;

Taylor, I. .

ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND, 2006, 88 (07) :639-642

[10] Treatment for liver metastases from breast cancer: Results and prognostic factors [J].

Li, Xiao-Ping ;

Meng, Zhi-Qiang ;

Guo, Wei-Jian ;

Li, Jie .

WORLD JOURNAL OF GASTROENTEROLOGY, 2005, 11 (24) :3782-3787

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