DEVELOPMENTAL-CHANGES IN FREE D-ASPARTIC ACID IN THE CHICKEN-EMBRYO AND IN THE NEONATAL RAT

被引：147

作者：

NEIDLE, A

DUNLOP, DS

机构：

[1] Nathan S. Kline Institute for Psychiatric Research Orangeburg

来源：

LIFE SCIENCES | 1990年 / 46卷 / 21期

关键词：

D O I：

10.1016/0024-3205(90)90424-P

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Free D-aspartic acid was measured in fertilized chicken eggs, chicken embryos, and neonatal rats. In each tissue examined a maximum value was found at a characteristic time of development. For the chicken embryo brain, the maximum was 9% D at 11 days of incubation; for the retina, 20% D at 13 days of incubation. In the neonatal rat, as in the chicken embryo, D-aspartic acid continued to increase in the retina after that in the brain and other tissues had begun to decline. The maximum, 29% D, was found 7 days after birth. Thus in two phylogenetically distant species, similar developmental patterns of D-aspartic acid change were observed. Some data on similarities between the D/L aspartic acid ratios of adult chicken and rat tissues are also reported. In addition, the total D-aspartic acid content of the egg, including the embryo, increased from 44 nmol at day 1 to 159 nmol at day 12, showing that release from a bound form or de novo synthesis is a continuing process during development. © 1990.

引用

页码：1517 / 1522

页数：6

共 9 条

[1] DETERMINATION OF D-ASPARTATE AND L-ASPARTATE IN AMINO-ACID MIXTURES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AFTER DERIVATIZATION WITH A CHIRAL ADDUCT OF O-PHTHALDIALDEHYDE [J].