Role of Vitamin D as an Anti-Proliferative Compound on Prostate Cancer

被引：0

作者：

Kabir, Ahmad Humayan ^{[1
]}

Khan, Ferdhos ^{[2
]}

Sarkar, Mamunur Rashid ^{[1
]}

机构：

[1] Univ Rajshahi, Dept Bot, Rajshahi, Bangladesh

[2] Univ Turku, Dept Biochem & Food Chem, Turku, Finland

来源：

ACTA FACULTATIS MEDICAE NAISSENSIS | 2013年 / 30卷 / 03期

关键词：

anti-proliferative effect; prostate cancer; receptor; LNCaP cells; vitamin D;

D O I：

10.2478/afmnai-2013-0003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The reason of prostate cancer is the mutation in the prostate cell. The present study was aimed at determining the effects of different concentrations of vitamin D on the anti-proliferative action of 24,25(OH) 2D3 applied on LNCaP (cell line of human prostate cancer) cells. It was evident from the results that vitamin D having concentrations of 10(-9)nM showed the best anti-proliferative action on prostate cancer cells (LNCaP cells) compared to other concentrations used. Most of the receptors were expressed at 10(-9)nM resulting clear band in agarose gel image. Results also revealed that both nVDR and AR receptors (androgen receptors) were expressed well when treated with 10(-9)nM and 10(-10)nM concentrations of 24,25(OH)(2)D-3. These findings confirm the potential use of vitamin D as an anti-proliferative compound against prostate cancer cells.

引用

页码：123 / 127

页数：5

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