Role of Vitamin D as an Anti-Proliferative Compound on Prostate Cancer

被引：0
作者：
Kabir, Ahmad Humayan [1 ]
Khan, Ferdhos [2 ]
Sarkar, Mamunur Rashid [1 ]
机构：
[1] Univ Rajshahi, Dept Bot, Rajshahi, Bangladesh
[2] Univ Turku, Dept Biochem & Food Chem, Turku, Finland
来源：
ACTA FACULTATIS MEDICAE NAISSENSIS | 2013年 / 30卷 / 03期
关键词：
anti-proliferative effect; prostate cancer; receptor; LNCaP cells; vitamin D;
D O I：
10.2478/afmnai-2013-0003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The reason of prostate cancer is the mutation in the prostate cell. The present study was aimed at determining the effects of different concentrations of vitamin D on the anti-proliferative action of 24,25(OH) 2D3 applied on LNCaP (cell line of human prostate cancer) cells. It was evident from the results that vitamin D having concentrations of 10(-9)nM showed the best anti-proliferative action on prostate cancer cells (LNCaP cells) compared to other concentrations used. Most of the receptors were expressed at 10(-9)nM resulting clear band in agarose gel image. Results also revealed that both nVDR and AR receptors (androgen receptors) were expressed well when treated with 10(-9)nM and 10(-10)nM concentrations of 24,25(OH)(2)D-3. These findings confirm the potential use of vitamin D as an anti-proliferative compound against prostate cancer cells.
引用
收藏
页码：123 / 127
页数：5
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