INVITRO ACTIVITY OF CYCLOGUANIL AGAINST AFRICAN ISOLATES OF PLASMODIUM-FALCIPARUM

被引：4

作者：

BASCO, LK ^{[1
]}

RAMILIARISOA, O ^{[1
]}

RINGWALD, P ^{[1
]}

DOURY, JC ^{[1
]}

LEBRAS, J ^{[1
]}

机构：

[1] SERV SANTE ARMEES,INST MED TROP,F-13998 MARSEILLE,FRANCE

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 04期

关键词：

D O I：

10.1128/AAC.37.4.924

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro activity of cycloguanil was assessed against 86 African isolates of Plasmodium falciparum by a semi-micro assay system. A bimodal distribution of susceptibility patterns was observed, with 44% of the isolates being cycloguanil susceptible. Cycloguanil alone retains a high activity against the intraerythrocytic forms of some isolates and, together with its activity against the hepatic stages, may be useful for chemoprophylaxis when combined with chloroquine.

引用

页码：924 / 925

页数：2

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