INVITRO ACTIVITY OF CYCLOGUANIL AGAINST AFRICAN ISOLATES OF PLASMODIUM-FALCIPARUM

被引:4
作者
BASCO, LK [1 ]
RAMILIARISOA, O [1 ]
RINGWALD, P [1 ]
DOURY, JC [1 ]
LEBRAS, J [1 ]
机构
[1] SERV SANTE ARMEES,INST MED TROP,F-13998 MARSEILLE,FRANCE
关键词
D O I
10.1128/AAC.37.4.924
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The in vitro activity of cycloguanil was assessed against 86 African isolates of Plasmodium falciparum by a semi-micro assay system. A bimodal distribution of susceptibility patterns was observed, with 44% of the isolates being cycloguanil susceptible. Cycloguanil alone retains a high activity against the intraerythrocytic forms of some isolates and, together with its activity against the hepatic stages, may be useful for chemoprophylaxis when combined with chloroquine.
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收藏
页码:924 / 925
页数:2
相关论文
共 12 条
[1]   ACTIVITY OF DIHYDROFOLATE-REDUCTASE INHIBITORS ON THE HEPATIC STAGES OF PLASMODIUM-YOELII YOELII INVITRO [J].
ERIKSSON, B ;
COURTIER, B ;
BJORKMAN, A ;
MILTGEN, F ;
MAZIER, D .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1991, 85 (06) :725-726
[2]  
FISK TL, 1988, AM J TROP MED HYG, V40, P235
[3]   AMINO-ACIDS IN THE DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE GENE OF PLASMODIUM-FALCIPARUM INVOLVED IN CYCLOGUANIL RESISTANCE DIFFER FROM THOSE INVOLVED IN PYRIMETHAMINE RESISTANCE [J].
FOOTE, SJ ;
GALATIS, D ;
COWMAN, AF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :3014-3017
[4]   PROLONGED MALARIA PROPHYLAXIS WITH CHLOROQUINE AND PROGUANIL (CHLOROGUANIDE) IN A NONIMMUNE RESIDENT POPULATION OF AN ENDEMIC AREA WITH A HIGH PREVALENCE OF CHLOROQUINE RESISTANCE [J].
GOZAL, D ;
HENGY, C ;
FADAT, G .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (02) :373-376
[5]   A COMPARISON OF THE PYRIMETHAMINE AND CYCLOGUANIL SENSITIVITIES OF THE PRE-ERYTHROCYTIC AND ERYTHROCYTIC STAGES OF DRUG-SENSITIVE AND DRUG-RESISTANT STRAINS OF PLASMODIUM-YOELII [J].
HOWELLS, RE ;
GILLES, HM ;
BENT, NS .
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1985, 79 (03) :247-251
[6]  
LEBRAS J, 1983, AM J TROP MED HYG, V32, P447
[7]  
Peters W, 1987, CHEMOTHERAPY DRUG RE
[8]   INVITRO AND INVIVO SUSCEPTIBILITY OF PLASMODIUM-FALCIPARUM ISOLATES FROM LIBERIA TO PYRIMETHAMINE, CYCLOGUANIL AND CHLORCYCLOGUANIL [J].
PETERSEN, E ;
HOGH, B ;
HANSON, AP ;
BJORKMAN, A ;
FLACKS, H .
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1990, 84 (06) :563-571
[9]   MOLECULAR-BASIS OF DIFFERENTIAL RESISTANCE TO CYCLOGUANIL AND PYRIMETHAMINE IN PLASMODIUM-FALCIPARUM MALARIA [J].
PETERSON, DS ;
MILHOUS, WK ;
WELLEMS, TE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :3018-3022
[10]   INVITRO SUSCEPTIBILITY OF PLASMODIUM-FALCIPARUM ISOLATES FROM JILORE, KENYA, TO ANTIMALARIAL-DRUGS [J].
WATKINS, WM ;
HOWELLS, RE ;
BRANDLINGBENNETT, AD ;
KOECH, DK .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1987, 37 (03) :445-451