LAMININ-A-RELATED DOMAINS IN CRB PROTEIN OF DROSOPHILA AND THEIR POSSIBLE ROLE IN EPITHELIAL POLARIZATION

被引：17

作者：

PATTHY, L

机构：

[1] Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, H-1518

来源：

FEBS LETTERS | 1991年 / 289卷 / 01期

关键词：

LAMININ; EPITHELIAL POLARIZATION; PROTEIN EVOLUTION;

D O I：

10.1016/0014-5793(91)80917-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is shown that four domains of the integral membrane protein crb of Drosophila are homologous with five C-terminal domains of the laminin A chain and merosin. Since the latter domains of laminin A have been implicated in determining epithelial polarity, the homology may suggest a similar function for these domains of crb. Such a function would be consistent with the known importance of crb for organization of epithelia in Drosophila.

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页码：99 / 101

页数：3

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