FROM MOLECULES TO CELLS - IMAGING SOFT SAMPLES WITH THE ATOMIC FORCE MICROSCOPE

被引：790

作者：

RADMACHER, M ^{[1
]}

TILLMANN, RW ^{[1
]}

FRITZ, M ^{[1
]}

GAUB, HE ^{[1
]}

机构：

[1] TECH UNIV MUNICH,DEPT PHYS,W-8046 GARCHING,GERMANY

来源：

SCIENCE | 1992年 / 257卷 / 5078期

关键词：

D O I：

10.1126/science.1411505

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Since its invention a few years ago, the atomic force microscope has become one of the most widely used near-field microscopes. Surfaces of hard samples are imaged routinely with atomic resolution. Soft samples, however, remain challenging. An overview is presented on the application of atomic force microscopy to organic samples ranging from thin ordered films at molecular resolution to living cells. Fundamental mechanisms of the image formation are discussed, and novel imaging modes are introduced that exploit different aspects of the tip-sample interaction for local measurements of the micromechanical properties of the sample. As examples, images of Langmuir-Blodgett films, which map the local viscoelasticity as well as the friction coefficient, are presented.

引用

页码：1900 / 1905

页数：6

共 72 条

[1] IMPROVED ATOMIC FORCE MICROSCOPE IMAGES USING MICROCANTILEVERS WITH SHARP TIPS [J].