BIOCHEMICAL BONE MARKERS AS PREDICTORS OF BONE LOSSES FOLLOWING LIVER TRANSPLANTATION

被引:0
作者
Buzulina, V. P. [1 ]
Pronchenko, I. A. [1 ]
Yermakova, I. P. [1 ]
Yaroshenko, E. B. [1 ]
Kornilov, M. N. [1 ]
Shmerko, N. P. [1 ]
机构
[1] Academician VI Shumakov Fed Res Ctr Transplantol, Moscow, Russia
来源
VESTNIK TRANSPLANTOLOGII I ISKUSSTVENNYH ORGANOV | 2010年 / 12卷 / 03期
关键词
orthotopic liver transplantation; bone mineral density; bone turnover; biochemical bone markers;
D O I
暂无
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
24 recipients after ortotopic liver transplantation (9 women and 5 men) 18-57 years aged were studied in 1-2 and then through 4-18 months following operation. Bone mineral density (BMD) in repeated estimation in 13 recipients was elevated on 14 +/- 10,5% and in 11 recipients was decreased on 2,5 +/- 2,56%. BMD elevation was associated with bone remodelling normalization. BMD lowering followed transplant dysfunction, glucocorticoid therapy, bone resorption increasing and bone formation suppression.
引用
收藏
页码:52 / 61
页数:10
相关论文
共 18 条
  • [1] Effects of alendronate on bone mineral density and bone metabolic markers in patients with liver transplantation
    Atamaz, F.
    Hepguler, S.
    Akyildiz, M.
    Karasu, Z.
    Kilic, M.
    [J]. OSTEOPOROSIS INTERNATIONAL, 2006, 17 (06) : 942 - 949
  • [2] Bjoro K, 2003, SCAND J GASTROENTERO, V38, P320, DOI 10.1080/00365520310000681
  • [3] Bone disorders in chronic liver disease
    Collier, Jane
    [J]. HEPATOLOGY, 2007, 46 (04) : 1271 - 1278
  • [4] Osteoporosis after liver transplantation
    Compston, JE
    [J]. LIVER TRANSPLANTATION, 2003, 9 (04) : 321 - 330
  • [5] Zoledronic acid prevents bone loss after liver transplantation - A randomized, double-blind, placebo-controlled trial
    Crawford, BAL
    Kam, C
    Pavlovic, J
    Byth, K
    Handelsman, DJ
    Angus, PW
    McCaughan, GW
    [J]. ANNALS OF INTERNAL MEDICINE, 2006, 144 (04) : 239 - 248
  • [6] The heterogeneity of bone disease in cirrhosis: a multivariate analysis
    Crawford, BAL
    Kam, C
    Donaghy, AJ
    McCaughan, GW
    [J]. OSTEOPOROSIS INTERNATIONAL, 2003, 14 (12) : 987 - 994
  • [7] Bone density, vitamin D status, and disordered bone remodeling in end-stage chronic liver disease
    Crosbie, OM
    Freaney, R
    McKenna, MJ
    Hegarty, JE
    [J]. CALCIFIED TISSUE INTERNATIONAL, 1999, 64 (04) : 295 - 300
  • [8] De Kroon L, 2007, NETH J MED, V65, P252
  • [9] Bone metabolism and gonad function in male patients undergoing liver transplantation: A two-year longitudinal study
    Floreani, A
    Mega, A
    Tizian, L
    Burra, P
    Boccagni, P
    Baldo, V
    Fagiuoli, S
    Naccarato, R
    Luisetto, G
    [J]. OSTEOPOROSIS INTERNATIONAL, 2001, 12 (09) : 749 - 754
  • [10] Long-term persistence of low bone density in orthotopic liver transplantation
    Giannini, S
    Nobile, M
    Ciuffreda, M
    Iemmolo, RM
    Carbonare, LD
    Minicuci, N
    Casagrande, F
    Destro, C
    Gerunda, GE
    Sartori, L
    Crepaldi, G
    [J]. OSTEOPOROSIS INTERNATIONAL, 2000, 11 (05) : 417 - 424