SIMPLIFIED AND COST-EFFECTIVE SYNTHESES OF FULLY PROTECTED PHOSPHORAMIDITE MONOMERS SUITABLE FOR THE ASSEMBLY OF OLIGO(2'-O-ALLYLRIBONUCLEOTIDES)

被引：21

作者：

BEIJER, B ^{[1
]}

GROTLI, M ^{[1
]}

DOUGLAS, ME ^{[1
]}

SPROAT, BS ^{[1
]}

机构：

[1] EUROPEAN MOLEC BIOL LAB, D-69117 HEIDELBERG, GERMANY

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1994年 / 13卷 / 09期

关键词：

D O I：

10.1080/15257779408010672

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Simplified, high yielding syntheses of suitably protected 2'-O-allylribonucleoside-3'-O-phosphoramidites starting from standard ribonucleosides have been elucidated. Specific 2'-O-allylation is readily achieved using amidine protection of the exocyclic amino groups of adenosine and cytidine and in the case of guanosine the allylation is carried out on an easily prepared intermediate bearing transient protection of the lactam function.

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页码：1905 / 1927

页数：23

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