GUILT BY INSOLUBILITY - DOES A PROTEINS DETERGENT INSOLUBILITY REFLECT CAVEOLAR LOCATION

被引：75

作者：

KURZCHALIA, T ^{[1
]}

HARTMANN, E ^{[1
]}

DUPREE, P ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT PLANT SCI,CAMBRIDGE CB2 3EA,ENGLAND

来源：

TRENDS IN CELL BIOLOGY | 1995年 / 5卷 / 05期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0962-8924(00)88990-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Several recent papers have described a simple approach to isolate caveolae and proteins involved in apical sorting in epithelial cells that is based on their detergent insolubility. These publications have excited such diverse fields of cell biology as intracellular protein transport, signal transduction and, in particular research into caveolae. In this article Kurzchalia, Hartmann and Dupree argue that a more critical evaluation of this detergent insolubility is needed before a subcellular location or function can be ascribed to a protein.

引用

页码：187 / 189

页数：3

共 30 条

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