DIFLUORINATION OF ESTERS - PREPARATION OF ALPHA,ALPHA-DIFLUORO ETHERS

Due to the extraordinary biological, physical, and chemical properties of organofluorine compounds,1methods for the tactical placement of fluorine into organic structures are of considerable interest. Since many of the available fluorinating agents are difficult to handle and/or require specialized apparatus, much of organofluorine chemistry remains outside the mainstream of synthetic methodology. The development and subsequent commercial availability of diethylaminosulfur trifluoride (DAST)2and its relatives has opened the field of organic fluorination to the general synthetic community, since these materials can be handled using standard techniques and apparatus. © 1990, American Chemical Society. All rights reserved.