THE EFFECT OF ANTIADHESION MOLECULE ANTIBODY ON THE DEVELOPMENT OF COLLAGEN-INDUCED ARTHRITIS

被引：84
|
作者：
KAKIMOTO, K
NAKAMURA, T
ISHII, K
TAKASHI, T
IIGOU, H
YAGITA, H
OKUMURA, K
ONOUE, K
机构：
[1] DAIICHI PHARMACEUT CO LTD,TOKYO RES & DEV CTR,TOKYO,JAPAN
[2] NAGASAKI UNIV,SCH DENT,DEPT RADIOL,NAGASAKI 852,JAPAN
[3] JUNTENDO UNIV,SCH MED,DEPT IMMUNOL,TOKYO 113,JAPAN
来源：
CELLULAR IMMUNOLOGY | 1992年 / 142卷 / 02期
关键词：
D O I：
10.1016/0008-8749(92)90294-Y
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In order to study how inflammatory cells including autoimmune lymphocytes interact with each other to develop collagen-induced arthritis (CIA), we injected monoclonal antibodies against mouse LFA-1 and ICAM-1 into DBA/1 mice immunized with type II collagen (CII). Both antibodies suppressed the development of CIA. These antibodies showed no effect on anti-CII antibody response, although they both significantly suppressed DTH response. It was suggested that antiadhesion molecule antibodies suppress CIA mainly through their effect on cell-mediated immunity, without affecting humoral immunity under the conditions used. © 1992.
引用
收藏
页码：326 / 337
页数：12
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