INHALED NITRIC-OXIDE IN PERSISTENT PULMONARY-HYPERTENSION OF THE NEWBORN

被引：697

作者：

ROBERTS, JD ^{[1
]}

POLANER, DM ^{[1
]}

LANG, P ^{[1
]}

ZAPOL, WM ^{[1
]}

机构：

[1] MASSACHUSETTS GEN HOSP,DEPT PEDIAT,BOSTON,MA 02114

来源：

LANCET | 1992年 / 340卷 / 8823期

关键词：

D O I：

10.1016/0140-6736(92)92686-A

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nitric oxide (NO) has vasodilatory effects on the pulmonary vasculature in adults and animals. We examined the effects on systemic oxygenation and blood pressure of inhaling up to 80 parts per million by volume of NO at F(i)O2 0.9 for up to 30 minutes by 6 infants with persistent pulmonary hypertension of the newborn (PPHN). In all infants this treatment rapidly and significantly increased preductal oxygen saturation (SpO2); in 5 infants postductal SpO2 and oxygen tensions also increased. Inhalation of NO did not cause systemic hypotension or raise methaemoglobin. These data suggest that low levels of inhaled NO have an important role in the reversal of hypoxaemia due to PPHN.

引用

页码：818 / 819

页数：2

共 8 条

[1] 2 CASES OF POISONING BY CONTAMINATION OF NITROUS OXIDE WITH HIGHER OXIDES OF NITROGEN DURING ANAESTHESIA [J].