THE ROLE OF CELL-DIVISION IN THE INDUCTION OF CLONAL ANERGY

被引：216
|
作者：
JENKINS, MK
机构：
[1] Marc Jenkins is at the Dept of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455
来源：
IMMUNOLOGY TODAY | 1992年 / 13卷 / 02期
关键词：
D O I：
10.1016/0167-5699(92)90137-V
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The interaction of antigen with lymphocyte antigen receptors can result in either clonal expansion or unresponsiveness (anergy). In 1970, Bretscher and Cohn proposed a two-signal model of lymphocyte activation to explain this paradox: antigen receptor occupancy alone could induce unresponsiveness whereas antigen receptor occupancy plus a costimulatory signal could induce immunity. Here, Marc Jenkins reviews in vitro and in vivo manifestations of clonal anergy and evaluates the ability of the two-signal model to explain these phenomena.
引用
收藏
页码：69 / 73
页数：5
相关论文
共 50 条
  • [31] CELL-DIVISION AND AGING
    KENT, S
    GERIATRICS, 1978, 33 (08) : 81 - +
  • [32] T-CELL CLONAL ANERGY
    SCHWARTZ, RH
    MUELLER, DL
    JENKINS, MK
    QUILL, H
    IMMUNOLOGICAL RECOGNITION, PTS 1 AND 2, 1989, 54 : 605 - 610
  • [33] T-CELL CLONAL ANERGY
    GILBERT, KM
    MECHANISMS OF IMMUNE REGULATION, 1994, 58 : 92 - 116
  • [34] CELL-DIVISION IN TETRASPORA
    PICKETTHEAPS, JD
    ANNALS OF BOTANY, 1973, 37 (153) : 1017 - +
  • [35] Irradiation and cell-division
    不详
    LANCET, 1926, 2 : 760 - 761
  • [36] LIPEMIA AND CELL-DIVISION
    BARER, R
    GUPTA, M
    JACOB, S
    JOSEPH, S
    OMINIABOHS, F
    JOURNAL OF ANATOMY, 1977, 123 (FEB) : 234 - 235
  • [37] CELL-DIVISION IN TETRAHEDRON
    PICKETTHEAPS, JD
    ANNALS OF BOTANY, 1972, 36 (147) : 693 - +
  • [38] T-CELL CLONAL ANERGY
    SCHWARTZ, RH
    MUELLER, DL
    JENKINS, MK
    QUILL, H
    COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1989, 54 : 605 - 610
  • [39] INDUCTION OF CELL-DIVISION OF ISOLATED POLLEN GRAINS BY SUGAR STARVATION IN RICE
    OGAWA, T
    FUKUOKA, H
    OHKAWA, Y
    BREEDING SCIENCE, 1994, 44 (01) : 75 - 77
  • [40] INDUCTION OF SYNCHRONOUS CELL-DIVISION IN PLATYMONAS-STRIATA BUTCHER (PRASINOPHYCEAE)
    RICKETTS, TR
    BRITISH PHYCOLOGICAL JOURNAL, 1979, 14 (03): : 219 - 223
12345