INTERLEUKIN-2 PRODUCTION BY PRIMARY ADULT T-CELL LEUKEMIA TUMOR-CELLS IS MACROPHAGE DEPENDENT

被引：7

作者：

ARIMA, N ^{[1
]}

DAITOKU, Y ^{[1
]}

HIDAKA, S ^{[1
]}

YAMAMOTO, Y ^{[1
]}

FUJIMOTO, K ^{[1
]}

MATSUSHITA, K ^{[1
]}

OHTSUBO, H ^{[1
]}

FUKUMORI, J ^{[1
]}

TANAKA, H ^{[1
]}

ONOUE, K ^{[1
]}

机构：

[1] KUMAMOTO UNIV,INST MED IMMUNOL,DEPT BIOCHEM,KUMAMOTO 860,JAPAN

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1992年 / 41卷 / 04期

关键词：

ATL; CYTOKINES; IL-2; PRODUCTION;

D O I：

10.1002/ajh.2830410407

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have investigated the cellular requirements for IL-2 production by autocrine proliferating tumor cells from four patients with adult T cell leukemia (ATL). Cultures of these ATL cells both produced endogenous IL-2 protein in the absence of added mitogen and proliferated at higher levels when exogenous recombinant IL-2 was added. Depletion of macrophages in the tumor cell cultures resulted in a sharp decline in tumor cell IL-2 production, while re-addition of macrophages reconstituted this response. Macrophage-derived factors including IL-6 and IL-1 also reconstituted IL-2 production in these macrophage depleted cultures. These results raise the possibility that macrophages may play a central role in HTLV-I mediated immortalization of T cells.

引用

页码：258 / 263

页数：6

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