PREPARATION AND SOME PROPERTIES OF COBALT(III) COMPLEXES WITH 1-THIO-BETA-D-GLUCOSE (H5TG) - CRYSTAL-STRUCTURE OF DELTA(D)-[CO(H3TG-O,S)(EN)2]NO3

Cobalt(III) complexes with 1-thio-beta-D-glucose (H5tg), [Co(H4tg-S)2{(en)2 or (tren)}]+ and [Co(H3tg-O, S){(en)2 or (tren)}]+, were newly prepared; where en and tren denote ethylenediamine and tris(2-aminoethyl)-amine, respectively. The oxidation products of [Co(H3tg-O,S){(en)2 or (tren)}]+ were prepared by the addition of H2O2. These complexes were separated into their isomers by column chromatography. The crystal structure of (+)230CD-[Co(H3tg-O,S) (en)2]NO3.H2O was determined by X-ray diffraction: This complex, chemical formula CoC10H16O8N5S, crystallizes in orthorhombic, space group P2(1)2(1)2(1), a = 14.328(1), b = 14.617(1), c = 8.605(1) angstrom, V = 1802.2(3) angstrom3, Z = 4, and R = 0.055. The geometry around the cobalt atom is approximately octahedral, coordinates by one 1-thio-beta-D-glucose and two en ligands. 1-Thio-beta-D-glucose takes the cyclic chair form and coordinates to cobalt(III) ion through the close-neighboring sulfur and oxygen atoms. This (+)230(CD) isomer takes the DELTA configuration. The other complexes were characterized by their absorption, CD, C-13 NMR spectra. For all of the isomers, the DELTA configuration will be more preferentially formed than the LAMBDA one.