DESIGN, SYNTHESIS AND PHARMACOLOGY OF CANNABIMIMETIC INDOLES

被引：204

作者：

HUFFMAN, JW ^{[1
]}

DAI, D ^{[1
]}

MARTIN, BR ^{[1
]}

COMPTON, DR ^{[1
]}

机构：

[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOL,RICHMOND,VA 23298

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)80155-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Molecular modeling has been employed to design a new group of cannabimimetic 1-alkyl-2-methyl-3-(1-naphthoyl)indoles. Cannabinoid activity was evaluated in vivo in the mouse and in vitro by determining the binding to the cannabinoid receptor. Maximum activity was found for the 1-butyl, pentyl and hexyl analogs. A rationalization for the alignment of these indoles with traditional cannabinoids is presented

引用

页码：563 / 566

页数：4

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