THE MANAGEMENT OF HEART-TRANSPLANT RECIPIENTS TREATED WITH CYCLOSPORINE IN IRELAND - MONITORING OF CYCLOSPORINE CONCENTRATIONS IN BLOOD

被引:1
作者
KYNE, F [1 ]
MAGUIRE, S [1 ]
UACONAILL, D [1 ]
OBROIN, S [1 ]
CLARKE, E [1 ]
MCCANN, S [1 ]
DERVAN, P [1 ]
WOOD, AE [1 ]
机构
[1] MATER MISERICORDIAE HOSP,DEPT BIOCHEM,DUBLIN 7,IRELAND
关键词
D O I
10.1007/BF02993610
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thirty seven cardiac transplants have taken place at the National Cardiac Centre in Ireland since 1985. Data is presented on three still-surviving male patients aged 19 to 42 who received cardiac transplants in 1985 and 1986. Circulating levels of blood cyclosporine were measured by high pressure liquid chromatography and radioimmunoassay; plasma creatinine and bilirubin were also measured. In one of these patients the distribution of cyclosporine in blood was measured by high pressure liquid chromatography in a long term study. For all three patients cyclosporine levels in blood were compared with the daily dose of cyclosporine and biochemical and histopathological parameters.
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页码:272 / 274
页数:3
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