THE TOXICITY OF AZIDOTHYMIDINE (AZT) IN THE TREATMENT OF PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

被引：1691

作者：

RICHMAN, DD

FISCHL, MA

GRIECO, MH

GOTTLIEB, MS

VOLBERDING, PA

LASKIN, OL

LEEDOM, JM

GROOPMAN, JE

MILDVAN, D

HIRSCH, MS

JACKSON, GG

DURACK, DT

NUSINOFFLEHRMAN, S

机构：

[1] UNIV MIAMI,CORAL GABLES,FL 33124

[2] ST LUKES ROOSEVELT HOSP CTR,NEW YORK,NY 10025

[3] UNIV CALIF LOS ANGELES,LOS ANGELES,CA 90024

[4] UNIV CALIF SAN FRANCISCO,SAN FRANCISCO,CA 94143

[5] CORNELL UNIV,MED CTR,COLL MED,NEW YORK,NY 10021

[6] UNIV SO CALIF,LOS ANGELES CTY MED CTR,LOS ANGELES,CA 90033

[7] HARVARD UNIV,NEW ENGLAND DEACONESS HOSP,BOSTON,MA 02215

[8] HARVARD UNIV,MASSACHUSETTS GEN HOSP,BOSTON,MA 02114

[9] BETH ISRAEL MED CTR,NEW YORK,NY 10003

[10] UNIV ILLINOIS,CHICAGO,IL 60680

[11] DUKE UNIV,MED CTR,DURHAM,NC 27710

[12] BURROUGHS WELLCOME CO,RES TRIANGLE PK,NC 27709

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 1987年 / 317卷 / 04期

关键词：

D O I：

10.1056/NEJM198707233170402

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：192 / 197

页数：6

共 15 条

[1]

CABALLERO GA, 1985, CANCER TREAT REP, V69, P13

[2]

DEMIRANDA P, 1986, INT C AIDS PARIS

[3] THE EFFICACY OF AZIDOTHYMIDINE (AZT) IN THE TREATMENT OF PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

FISCHL, MA ;

RICHMAN, DD ;

GRIECO, MH ;

GOTTLIEB, MS ;

VOLBERDING, PA ;

LASKIN, OL ;

LEEDOM, JM ;

GROOPMAN, JE ;

MILDVAN, D ;

SCHOOLEY, RT ;

JACKSON, GG ;

DURACK, DT ;

KING, D .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (04) :185-191

[4] PHOSPHORYLATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE AND SELECTIVE INTERACTION OF THE 5'-TRIPHOSPHATE WITH HUMAN-IMMUNODEFICIENCY-VIRUS REVERSE-TRANSCRIPTASE [J].

FURMAN, PA ;

FYFE, JA ;

STCLAIR, MH ;

WEINHOLD, K ;

RIDEOUT, JL ;

FREEMAN, GA ;

LEHRMAN, SN ;

BOLOGNESI, DP ;

BRODER, S ;

MITSUYA, H ;

BARRY, DW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (21) :8333-8337

[5]

GOOD SS, 1986, FASEB J, V45, P444

[6]

MANTEL N, 1959, J NATL CANCER I, V22, P719

[7] 3'-AZIDO-3'-DEOXYTHYMIDINE (BW A509U) - AN ANTIVIRAL AGENT THAT INHIBITS THE INFECTIVITY AND CYTOPATHIC EFFECT OF HUMAN LYMPHOTROPIC-T VIRUS TYPE-III LYMPHADENOPATHY-ASSOCIATED VIRUS INVITRO [J].

MITSUYA, H ;

WEINHOLD, KJ ;

FURMAN, PA ;

STCLAIR, MH ;

LEHRMAN, SN ;

GALLO, RC ;

BOLOGNESI, D ;

BARRY, DW ;

BRODER, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (20) :7096-7100

[8]

MROCHEK JE, 1974, CLIN CHEM, V20, P1086

[9] KINETICS OF METABOLISM OF ACETAMINOPHEN BY HUMANS [J].

NELSON, E ;

MORIOKA, T .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1963, 52 (09) :864-&

[10] INCREASED GLUCURONIDATION OF BILIRUBIN IN MAN AND RAT BY ADMINISTRATION OF ANTIPYRINE (PHENAZONE) [J].

ORME, ML ;

DAVIES, L ;

BRECKENRIDGE, A .

CLINICAL SCIENCE AND MOLECULAR MEDICINE, 1974, 46 (04) :511-518

← 1 2 →