The versatile functions of Sox9 in development, stem cells, and human diseases

被引：282
作者：
Jo, Alice [1 ]
Denduluri, Sahitya [1 ]
Zhang, Bosi [1 ]
Wang, Zhongliang [1 ,2 ,3 ]
Yin, Liangjun [1 ,2 ,3 ]
Yan, Zhengjian [1 ,2 ,3 ]
Kang, Richard [1 ]
Shi, Lewis L. [1 ]
Mok, James [1 ]
Lee, Michael J. [1 ]
Haydon, Rex C. [1 ]
机构：
[1] Univ Chicago, Med Ctr, Dept Orthopaed Surg & Rehabil Med, Mol Oncol Lab, Chicago, IL 60637 USA
[2] Chongqing Med Univ, Affiliated Hosp, Dept Orthopaed, Chongqing 400046, Peoples R China
[3] Chongqing Med Univ, Affiliated Hosp, Dept Surg, Chongqing 400046, Peoples R China
来源：
GENES & DISEASES | 2014年 / 1卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Development; Sox9; Stem cells; Transcription factor;
D O I：
10.1016/j.gendis.2014.09.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The transcription factor Sox9 was first discovered in patients with campomelic dysplasia, a haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 expression during chondrogenesis. Since then, its role as a cell fate determiner during embryonic development has been well characterized; Sox9 expression differentiates cells derived from all three germ layers into a large variety of specialized tissues and organs. However, recent data has shown that ectoderm- and endoderm-derived tissues continue to express Sox9 in mature organs and stem cell pools, suggesting its role in cell maintenance and specification during adult life. The versatility of Sox9 may be explained by a combination of post-transcriptional modifications, binding partners, and the tissue type in which it is expressed. Considering its importance during both development and adult life, it follows that dysregulation of Sox9 has been implicated in various congenital and acquired diseases, including fibrosis and cancer. This review provides a summary of the various roles of Sox9 in cell fate specification, stem cell biology, and related human diseases. Ultimately, understanding the mechanisms that regulate Sox9 will be crucial for developing effective therapies to treat disease caused by stem cell dysregulation or even reverse organ damage. Copyright (C) 2014, Chongqing Medical University. Production and hosting by Elsevier B.V. All rights reserved.
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页码：149 / 161
页数：13
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