The Emerging Role of Stereotactic Radiosurgery in the Treatment of Glioblastoma Multiforme

被引:6
作者
Barbarisi, Manlio [1 ]
Romanelli, Pantaleo [2 ]
机构
[1] Univ Naples 2, Dept Neurosurg, Naples, Italy
[2] Ctr Diagnost Italiano, CyberKnife Ctr, Brain Radiosurg, Via St Bon 20, I-20147 Milan, Italy
关键词
Fractionated stereotactic radiotherapy; Glioblastoma multiforme; image-guidance; stereotactic radiosurgery;
D O I
10.2174/1874471011205040292
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Stereotactic radiosurgery is an emerging treatment option offered to patients with Glioblastoma multiforme (GBM). Radiosurgery is performed as an outpatient procedure and provides a safe and effective non invasive treatment for focal GBM. High energy beams originating from cobalt sources placed into an helmet (Gamma-Knife) or generated by a linear accelerator (LINAC) rotating on a gantry (X-Knife, Novalis) or maneuvered by a robotic arm (CyberKnife) are delivered with submillimetric accuracy to a selected intracranial target. Treatment accuracy is provided by image-guided volumetric CT and MR studies complemented with advanced metabolic neuroimaging techniques such as CT-PET. Radiosurgery is typically used as a salvage treatment in patients with recurrent GBM to avoid further surgical procedures or as a complement to conventional fractionated radiotherapy. This paper reviews the emerging role of stereotactic radiosurgery in the treatment of GBM.
引用
收藏
页码:292 / 299
页数:8
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