Biocatalyst behaviour in low-water systems

被引:178
作者
Bell, G
Halling, PJ
Moore, BD
Partridge, J
Rees, DG
机构
[1] UNIV STRATHCLYDE, DEPT BIOSCI & BIOTECHNOL, GLASGOW G1 1XW, LANARK, SCOTLAND
[2] UNIV STRATHCLYDE, DEPT PURE & APPL CHEM, GLASGOW G1 1XW, LANARK, SCOTLAND
基金
英国生物技术与生命科学研究理事会;
关键词
D O I
10.1016/S0167-7799(00)89004-6
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
An improving understanding of the parameters that affect biocatalyst activity, specificity and stability in low-water non-aqueous media make reliable predictions about the behaviour of such systems increasingly feasible, Here, we discuss some of the key factors, such as control of water activity, and the effects of solvent on K-m and protein-ionization state, that must be addressed in order to obtain predictable results.
引用
收藏
页码:468 / 473
页数:6
相关论文
共 49 条
[1]   ON THE IMPORTANCE OF THE SUPPORT MATERIAL FOR ENZYMATIC-SYNTHESIS IN ORGANIC MEDIA - SUPPORT EFFECTS AT CONTROLLED WATER ACTIVITY [J].
ADLERCREUTZ, P .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 199 (03) :609-614
[2]   THERMOSTABILITY OF RIBONUCLEASE-A IN ORGANIC-SOLVENTS - A CALORIMETRIC AND SPECTROSCOPIC STUDY [J].
BATTISTEL, E ;
BIANCHI, D .
JOURNAL OF PHYSICAL CHEMISTRY, 1994, 98 (20) :5368-5375
[3]   ESTERIFICATION OF 2-METHYLALKANOIC ACIDS CATALYZED BY LIPASE FROM CANDIDA-RUGOSA - ENANTIOSELECTIVITY AS A FUNCTION OF WATER ACTIVITY AND ALCOHOL CHAIN-LENGTH [J].
BERGLUND, P ;
VORDE, C ;
HOGBERG, HE .
BIOCATALYSIS, 1994, 9 (1-4) :123-130
[4]   ORGANIC-PHASE BUFFERS CONTROL BIOCATALYST ACTIVITY INDEPENDENT OF INITIAL AQUEOUS PH [J].
BLACKWOOD, AD ;
CURRAN, LJ ;
MOORE, BD ;
HALLING, PJ .
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1994, 1206 (02) :161-165
[5]   EFFECTS OF WATER ACTIVITY ON V(MAX) AND K(M) OF LIPASE-CATALYZED TRANSESTERIFICATION IN ORGANIC MEDIA [J].
BOVARA, R ;
CARREA, G ;
OTTOLINA, G ;
RIVA, S .
BIOTECHNOLOGY LETTERS, 1993, 15 (09) :937-942
[6]   ROLE OF SOLVENTS IN THE CONTROL OF ENZYME SELECTIVITY IN ORGANIC MEDIA [J].
CARREA, G ;
OTTOLINA, G ;
RIVA, S .
TRENDS IN BIOTECHNOLOGY, 1995, 13 (02) :63-70
[7]   KINETIC-ANALYSIS OF THE MECHANISM FOR SUBTILISIN IN ESSENTIALLY ANHYDROUS ORGANIC-SOLVENTS [J].
CHATTERJEE, S ;
RUSSELL, AJ .
ENZYME AND MICROBIAL TECHNOLOGY, 1993, 15 (12) :1022-1029
[8]   DETERMINATION OF EQUILIBRIUM AND INDIVIDUAL RATE CONSTANTS FOR SUBTILISIN-CATALYZED TRANSESTERIFICATION IN ANHYDROUS ENVIRONMENTS [J].
CHATTERJEE, S ;
RUSSELL, AJ .
BIOTECHNOLOGY AND BIOENGINEERING, 1992, 40 (09) :1069-1077
[9]   INFLUENCE OF WATER ACTIVITY ON THE SYNTHESIS OF TRIOLEIN CATALYZED BY IMMOBILIZED MUCOR-MIEHEI LIPASE [J].
DUDAL, Y ;
LORTIE, R .
BIOTECHNOLOGY AND BIOENGINEERING, 1995, 45 (02) :129-134
[10]   ENZYMATIC CATALYSIS IN HETEROGENEOUS EUTECTIC MIXTURES OF SUBSTRATES [J].
GILL, I ;
VULFSON, E .
TRENDS IN BIOTECHNOLOGY, 1994, 12 (04) :118-122