AN ATTEMPT TO ATTENUATE EXPERIMENTAL PAIN IN HUMANS BY DEXTROMETHORPHAN, AN NMDA RECEPTOR ANTAGONIST

被引：44
作者：
KAUPPILA, T
GRONROOS, M
PERTOVAARA, A
机构：
[1] HELSINKI UNIV,DEPT PHYSIOL,SF-00014 HELSINKI,FINLAND
[2] UNIV TURKU,DEPT PHYSIOL,TURKU,FINLAND
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1995年 / 52卷 / 03期
关键词：
ANALGESIA; CAPSAICIN; DEXTROMETHORPHAN; N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST; PAIN MODULATION;
D O I：
10.1016/0091-3057(95)00106-7
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Dextromethorphan (100 mg, orally), an NMDA receptor antagonist, did not significantly attenuate pain intensity or unpleasantness induced by experimental ischemia or by topical capsaicin in healthy human subjects, nor did it increase the threshold for heat pain or mechanical pain. A dose of 200 mg produced marked side effects. Thus, systemically administered dextromethorphan does not attenuate pain at clinically applicable doses in humans.
引用
收藏
页码：641 / 644
页数：4
相关论文
共 33 条
[1]   RESPONSE OF CHRONIC NEUROPATHIC PAIN SYNDROMES TO KETAMINE - A PRELIMINARY-STUDY [J].
BACKONJA, M ;
ARNDT, G ;
GOMBAR, KA ;
CHECK, B ;
ZIMMERMANN, M .
PAIN, 1994, 56 (01) :51-57
[2]   DEXTROMETHORPHAN - AN OVERVIEW OF SAFETY ISSUES [J].
BEM, JL ;
PECK, R .
DRUG SAFETY, 1992, 7 (03) :190-199
[3]   DIFFERENTIAL-EFFECTS OF DEXTROPHAN AND LEVORPHANOL ON THE EXCITATION OF RAT SPINAL NEURONS BY AMINO-ACIDS [J].
CHURCH, J ;
LODGE, D ;
BERRY, SC .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 111 (02) :185-190
[4]   ANTITUSSIVE AGENTS AS N-METHYLASPARTATE ANTAGONISTS - FURTHER-STUDIES [J].
CHURCH, J ;
JONES, MG ;
DAVIES, SN ;
LODGE, D .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1989, 67 (06) :561-567
[5]  
CODERRE TJ, 1992, J NEUROSCI, V12, P3671
[6]   MK-801 BLOCKS THE DEVELOPMENT OF THERMAL HYPERALGESIA IN A RAT MODEL OF EXPERIMENTAL PAINFUL NEUROPATHY [J].
DAVAR, G ;
HAMA, A ;
DEYKIN, A ;
VOS, B ;
MACIEWICZ, R .
BRAIN RESEARCH, 1991, 553 (02) :327-330
[7]   EVIDENCE FOR INVOLVEMENT OF N-METHYLASPARTATE RECEPTORS IN WIND-UP OF CLASS-2 NEURONS IN THE DORSAL HORN OF THE RAT [J].
DAVIES, SN ;
LODGE, D .
BRAIN RESEARCH, 1987, 424 (02) :402-406
[8]   DEXTROMETHORPHAN AND LEVORPHANOL ON DORSAL HORN NOCICEPTIVE NEURONS IN THE RAT [J].
DICKENSON, AH ;
SULLIVAN, AF ;
STANFA, LC ;
MCQUAY, HJ .
NEUROPHARMACOLOGY, 1991, 30 (12A) :1303-1308
[9]   EVIDENCE FOR A ROLE OF THE NMDA RECEPTOR IN THE FREQUENCY-DEPENDENT POTENTIATION OF DEEP RAT DORSAL HORN NOCICEPTIVE NEURONS FOLLOWING C-FIBER STIMULATION [J].
DICKENSON, AH ;
SULLIVAN, AF .
NEUROPHARMACOLOGY, 1987, 26 (08) :1235-1238
[10]  
FRANCE CP, 1989, J PHARMACOL EXP THER, V250, P197
1234