REDUCTION OF EPIDERMAL GROWTH-FACTOR RECEPTOR AFFINITY BY HETEROLOGOUS LIGANDS - EVIDENCE FOR A MECHANISM INVOLVING THE BREAKDOWN OF PHOSPHOINOSITIDES AND THE ACTIVATION OF PROTEIN KINASE-C

被引:204
作者
BROWN, KD [1 ]
BLAY, J [1 ]
IRVINE, RF [1 ]
HESLOP, JP [1 ]
BERRIDGE, MJ [1 ]
机构
[1] UNIV CAMBRIDGE,DEPT ZOOL,AFRC,INSECT NEUROPHYSIOL & PHARMACOL UNIT,CAMBRIDGE CB2 3EJ,ENGLAND
关键词
D O I
10.1016/0006-291X(84)90424-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:377 / 384
页数:8
相关论文
共 31 条
[1]   IDENTIFICATION OF A CALCIUM-DEPENDENT AND PHOSPHOLIPID-DEPENDENT PHORBOL ESTER BINDING-ACTIVITY IN THE SOLUBLE FRACTION OF MOUSE-TISSUES [J].
ASHENDEL, CL ;
STALLER, JM ;
BOUTWELL, RK .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 111 (01) :340-345
[2]   INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL AS 2ND MESSENGERS [J].
BERRIDGE, MJ .
BIOCHEMICAL JOURNAL, 1984, 220 (02) :345-360
[3]   CHANGES IN THE LEVELS OF INOSITOL PHOSPHATES AFTER AGONIST-DEPENDENT HYDROLYSIS OF MEMBRANE PHOSPHOINOSITIDES [J].
BERRIDGE, MJ ;
DAWSON, RMC ;
DOWNES, CP ;
HESLOP, JP ;
IRVINE, RF .
BIOCHEMICAL JOURNAL, 1983, 212 (02) :473-482
[4]  
BERRIDGE MJ, 1984, BIOCH J
[5]   IS EPIDERMAL GROWTH-FACTOR PRESENT IN HUMAN-BLOOD - INTERFERENCE WITH THE RADIORECEPTOR ASSAY FOR EPIDERMAL GROWTH-FACTOR [J].
BOWENPOPE, DF ;
ROSS, R .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 114 (03) :1036-1041
[6]   INTERACTIONS BETWEEN THE RECEPTORS FOR PLATELET-DERIVED GROWTH-FACTOR AND EPIDERMAL GROWTH-FACTOR [J].
BOWENPOPE, DF ;
DICORLETO, PE ;
ROSS, R .
JOURNAL OF CELL BIOLOGY, 1983, 96 (03) :679-683
[7]   INHIBITION OF EPIDERMAL GROWTH-FACTOR BINDING TO SWISS-3T3 CELLS BY HUMAN-PLATELET RELEASE-PRODUCTS [J].
BROWN, KD ;
BLAKELEY, DM ;
MACDONALD, M .
BIOSCIENCE REPORTS, 1983, 3 (07) :659-666
[8]   INHIBITION OF EPIDERMAL GROWTH-FACTOR BINDING TO SURFACE RECEPTORS BY TUMOR PROMOTORS [J].
BROWN, KD ;
DICKER, P ;
ROZENGURT, E .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1979, 86 (04) :1037-1043
[9]   PARTIAL-PURIFICATION AND CHARACTERIZATION OF A GROWTH-FACTOR PRESENT IN GOATS COLOSTRUM - SIMILARITIES WITH PLATELET-DERIVED GROWTH-FACTOR [J].
BROWN, KD ;
BLAKELEY, DM .
BIOCHEMICAL JOURNAL, 1984, 219 (02) :609-617
[10]   INHIBITION OF THE BINDING OF I-125-LABELED EPIDERMAL GROWTH-FACTOR TO MOUSE CELLS BY A MITOGEN IN GOAT MAMMARY SECRETIONS [J].
BROWN, KD ;
BLAKELEY, DM .
BIOCHEMICAL JOURNAL, 1983, 212 (02) :465-472