Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles of Zidovudine in Rats

被引：15

作者：

Purvin, Shah ^{[1
]}

Vuddanda, Parameswara Rao ^{[1
]}

Singh, Sanjay Kumar ^{[1
]}

Jain, Achint ^{[1
]}

Singh, Sanjay ^{[1
]}

机构：

[1] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut, Varanasi 221005, Uttar Pradesh, India

来源：

JOURNAL OF NANOTECHNOLOGY | 2014年 / 2014卷 / 2014期

关键词：

D O I：

10.1155/2014/854018

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Zidovudine-loaded solid lipid nanoparticles (AZT-SLNs) and zidovudine in solution were prepared and administered in rats. The aim of this research was to study whether the bioavailability of zidovudine can be improved by AZT-SLNs perorally to rats as compared to oral administration of zidovudine. Zidovudine was determined in plasma and tissues by reverse phase high performance liquid chromatography. The pharmacokinetic parameters of zidovudinewere determined after peroral administration: area under curve of concentration versus time (AUC) for AZT-SLNs was 31.25% greater than AZT solution; meanwhile mean resident time (MRT) was found to be 1.83 times higher for AZT-SLNs than AZT solution. Elimination half life of zidovudine was also increased for SLNformulation. Tissue distribution pattern of zidovudinewas changed in case ofAZT-SLNs. AUCof zidovudine in brain and liver was found to be approximately 2.73 and 1.77 times higher inAZT-SLNs thanAZT solution, respectively, indicating that AZT-SLNs could cross blood brain barrier. Distribution of zidovudinewas approximately 0.95 and 0.86 times lesser in heart and kidney, respectively. It can be concluded fromthe study that oral administration of AZT-SLNs modifies the plasma pharmacokinetic parameters and biodistribution of zidovudine.

引用

页数：7

共 27 条

[1] In vivo evaluation of zidovudine (AZT)-loaded ethylcellulose microspheres after oral administration in Beagle dogs [J].