PLANT-BASED ANTIAMOEBIC DRUGS .5. THE MICROBIOLOGICAL TRANSFORMATION OF PARTHENIN BY BEAUVERIA-BASSIANA AND SPOROTRICHUM-PULVERULENTUM

被引：13
作者：
BHUTANI, KK
THAKUR, RN
机构：
来源：
PHYTOCHEMISTRY | 1991年 / 30卷 / 11期
关键词：
BEAUVERIA-BASSIANA; SPOROTRICHUM PULVERULENTUM; FUNGI; BIOTRANSFORMATION; PARTHENIUM-HYSTEROPHORUS; SESQUITERPENE LACTONE; PARTHENIN;
D O I：
10.1016/0031-9422(91)80073-A
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Incubation of parthenin (1,6-beta-dihydroxy-4-oxo-10-alpha-H-ambrosa-2,11(13)-dien-12-oic acid-gamma-lactone) with the fungus Beauveria bassiana affords the C-11 reduction product, 1,6-beta-dihydroxy-11-beta-methyl-4-oxo-10-alpha-H-ambrosa-2-ene-12-oic acid-gamma-lactone. A C-11 hydroxylation product, 1,6-beta,11-alpha-trihydroxy-11-beta-methyl-4-oxo-10-alpha-H-ambrosa-2-ene-12-oic acid-gamma-lactone was obtained from the broth of the fungus Sporotrichum pulverulentum using the same substrate.
引用
收藏
页码：3599 / 3600
页数：2
相关论文
共 7 条
[1]   PLANT-BASED ANTIAMOEBIC DRUGS .4. AN UNUSUAL OXIDATIVE DEMETHYLATION REACTION OF CONESSINE WITH N-BROMOSUCCINIMIDE [J].
BHUTANI, KK ;
VAID, RM .
TETRAHEDRON LETTERS, 1988, 29 (03) :359-360
[2]   STRUCTURES OF PARTHENIN AND AMBROSIN [J].
HERZ, W ;
KISHIDA, Y ;
WATANABE, H ;
MIYAZAKI, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1962, 84 (13) :2601-&
[3]   TUMOR INHIBITORS .69. STRUCTURE-CYTOTOXICITY RELATIONSHIPS AMONG SESQUITERPENE LACTONES [J].
KUPCHAN, SM ;
EAKIN, MA ;
THOMAS, AM .
JOURNAL OF MEDICINAL CHEMISTRY, 1971, 14 (12) :1147-&
[4]   ROLE OF SESQUITERPENE LACTONES IN CONTACT HYPERSENSITIVITY TO SOME NORTH AND SOUTH-AMERICAN SPECIES OF FEVERFEW (PARTHENIUM - COMPOSITAE) [J].
RODRIGUEZ, E ;
EPSTEIN, WL ;
MITCHELL, JC .
CONTACT DERMATITIS, 1977, 3 (03) :155-162
[5]   SESQUITERPENE LACTONE CHEMISTRY OF GENUS PARTHENIUM (COMPOSITAE) [J].
RODRIGUEZ, E ;
YOSHIOKA, H ;
MABRY, TJ .
PHYTOCHEMISTRY, 1971, 10 (05) :1145-+
[6]   PLANT BASED ANTIAMOEBIC DRUGS .2. AMEBICIDAL ACTIVITY OF PARTHENIN ISOLATED FROM PARTHENIUM-HYSTEROPHORUS [J].
SHARMA, GL ;
BHUTANI, KK .
PLANTA MEDICA, 1988, (02) :120-122
[7]  
Thakur R. N., 1982, Indian Phytopathology, V35, P516
1