COLON CANCER AND DIETARY FIBER - CELLULOSE INHIBITS THE DNA-DAMAGING ABILITY OF BILE-ACIDS

被引：16

作者：

CHEAH, PY

BERNSTEIN, H

机构：

[1] Department of Microbiology and Immunology and Committee on Genetics, College of Medicine, University of Arizona, Health Sciences Center, Tucson

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1990年 / 13卷 / 1-2期

关键词：

D O I：

10.1080/01635589009514044

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colon cancer is the second most common type of cancer in the United States. Bile acids have been implicated in the etiology of this disease. In a previous study, we showed that bile acids can damage DNA in vitro. In this study, we report that this damage is largely prevented when the bile acids are pretreated with cellulose fiber. Preliminary data show that cellulose may act as a catalyst to promote polyesterification of bile acid to a biologically inactive form. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：51 / 57

页数：7

共 20 条

[1]

Reddy B.S., Hedges A.R., Laakso K., Wynder E.L., Metabolic Epidemiology of Large Bowel Cancer, Cancer, 42, pp. 2832-2838, (1978)

[2]

Domellof L., Darby L., Hanson D., Mathews L., Simi B., Et al., Fecal Sterols and Bacterial β-Glucuronidase Activity: A Preliminary Metabolic Epidemiology Study of Healthy Volunteers From Umea, Sweden and Metropolitan New York, Nutr Cancer, 4, pp. 120-127, (1982)

[3]

Story J.A., Kritchevsky D., Comparison of the Binding of Various Bile Acids and Bile Salts in vitro by Several Types of Fiber, J Nutr, 106, pp. 1292-1294, (1976)

[4]

Bingham S.A., Epidemiology of Dietairy Fiber and Colorectal Cancer: Current Status of the Hypothesis, Dietary Fiber

[5]

Basic and Clinical Aspects, pp. 523-542, (1986)

[6]

Hill M.J., Bile Acids and Colorectal Cancer in Humans, Dietary Fiber—Basic and Clinical Aspects, pp. 497-513, (1986)

[7]

Burkitt D.P., Epidemiology of Cancer of the Colon and Rectum, Cancer, 28, pp. 3-13, (1971)

[8]

Reddy B.S., Sharma C., Simi B., Engle A., Laakso K., Et al., Metabolic Epidemiology of Colon Cancer: Effect of Dietary Fiber on Fecal Mutagens and Bile Acids in Healthy Subjects, Cancer Res, 47, pp. 644-648, (1987)

[9]

Pomare E.W., Heaton K.W., Low-Beei T.S., Espiner J.H., The Effect of Wheat Bran Upon the Lipid Composition of Bile in Gallstone Patients, Dig Dis, 21, pp. 521-526, (1976)

[10]

Watts J.M., Jablonski P., Toouli J., The Effect of Added Bran to the Diet on the Saturation of Bile in People Without Gallstones, Am J Suig, 135, pp. 321-324, (1978)

← 1 2 →