PHOSPHORUS-CONTAINING AMINOCARBOXYLIC ACIDS .5. METHOD FOR SYNTHESIS OF PHOSPHINIC ACIDS

被引：19

作者：

RAGULIN, VV

KURDYUMOVA, NR

TSVETKOV, EN

机构：

[1] Institute of Physiologically Active Substances, Russian Academy of Sciences, Moscow Region

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1994年 / 88卷 / 1-4期

关键词：

PHOSPHORUS CONTAINING AMINOCARBOXYLIC ACIDS BIS(TRIMETHYLSILYL)HYPOPHOSPHITE; DIETHYL OMEGA-BROMOALKYLACETOAMIDOMALONATE; STYRENE; ALCOHOLYSIS; HYDROLYSIS;

D O I：

10.1080/10426509408036931

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A facile method for the synthesis of phosphinic aminocarboxylic acids containing a lypophilic beta-phenylethyl radical at the phosphorus atom has been suggested. Bis(trimethylsilyl)hypophosphite, prepared from ammonium hypophosphite, is added to styrene, the phosphonite formed is further alkylated by the corresponding diethyl omega-bromoalkylacetoamidomalonate. Subsequent hydrolysis of beta-phenylethyl-phosphinylalkylacetoamidomalonates leads to the desired aminoacids.

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页码：271 / 274

页数：4

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