BIODISTRIBUTION AND MAGNETIC-RESONANCE-IMAGING OF CROSS-LINKED DTPA POLYSACCHARIDES

被引：21
作者：
GIBBY, WA
BILLINGS, J
HALL, J
OVITT, TW
机构：
[1] UNIV ARIZONA,DEPT RADIOL,TUCSON,AZ 85721
[2] UNIV PENN,DEPT RADIOL,PHILADELPHIA,PA 19104
来源：
INVESTIGATIVE RADIOLOGY | 1990年 / 25卷 / 02期
关键词：
Gd-; DTPA; MRI contrast agents; Polysaccharide polymers;
D O I：
10.1097/00004424-199002000-00012
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Large polysaccharide complexes, cross-linked with DTPA and chelated with gadolinium have been tested for various potential uses for magnetic resonance imaging (MRI) in rats. Bio distribution and pharmacokinetic data for several of the soluble polymers are presented and compared with Gd-DTPA and GdCl3. By varying the initial polysaccharide length and ratio of DTPA to glucose units, polymers of molecular weights (mol wt) from 17,000 to several million were formed, giving soluble material, gels, or particles. The larger polymers (mol wt > 100,000) demonstrate prolonged enhancement of the intravascular space, striking renal enhancement, and moderate hepatic uptake. Small particulate material (less than 10 /um) was also successfully used for intravascular enhancement. The material is metabolized and excreted in urine. © Lippincott-Raven Publishers.
引用
收藏
页码：164 / 172
页数：9
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