MODULATION OF ION-CHANNEL FUNCTION BY G-PROTEIN-COUPLED RECEPTORS

被引:682
作者
HILLE, B
机构
[1] Dept of Physiology and Biophysics, University of Washington, Seattle, WA 98195
基金
美国国家卫生研究院;
关键词
D O I
10.1016/0166-2236(94)90157-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neurotransmitters acting through G-protein-coupled receptors change the electrical excitability of neurons. Activation of receptors can affect the voltage dependence, the speed of gating, and the probability of opening of various ion channels, thus changing the computational state and outputs of a neuron. Each cell expresses many kinds of receptors, and uses several intracellular signaling pathways to modulate channel function in different ways. It has become possible to dissect these pathways by combining pharmacological and biophysical experiments. Recent patch-clamp work in sympathetic neurons will be summarized to illustrate the mechanisms underlying modulation and its significance.
引用
收藏
页码:531 / 536
页数:6
相关论文
共 73 条
[1]   SUBSTANCE-P INHIBITS THE M-CURRENT IN BULLFROG SYMPATHETIC NEURONS [J].
ADAMS, PR ;
BROWN, DA ;
JONES, SW .
BRITISH JOURNAL OF PHARMACOLOGY, 1983, 79 (02) :330-333
[2]   PHARMACOLOGICAL INHIBITION OF THE M-CURRENT [J].
ADAMS, PR ;
BROWN, DA ;
CONSTANTI, A .
JOURNAL OF PHYSIOLOGY-LONDON, 1982, 332 (NOV) :223-262
[3]   MYOSIN LIGHT-CHAIN KINASE OCCURS IN BULLFROG SYMPATHETIC NEURONS AND MAY MODULATE VOLTAGE-DEPENDENT POTASSIUM CURRENTS [J].
AKASU, T ;
ITO, M ;
NAKANO, T ;
SCHNEIDER, CR ;
SIMMONS, MA ;
TANAKA, T ;
TOKIMASA, T ;
YOSHIDA, M .
NEURON, 1993, 11 (06) :1133-1145
[4]   MODULATION OF VERTEBRATE NEURONAL CALCIUM CHANNELS BY TRANSMITTERS [J].
ANWYL, R .
BRAIN RESEARCH REVIEWS, 1991, 16 (03) :265-281
[6]   PERTUSSIS TOXIN AND VOLTAGE DEPENDENCE DISTINGUISH MULTIPLE PATHWAYS MODULATING CALCIUM CHANNELS OF RAT SYMPATHETIC NEURONS [J].
BEECH, DJ ;
BERNHEIM, L ;
HILLE, B .
NEURON, 1992, 8 (01) :97-106
[7]   INTRACELLULAR CA2+ BUFFERS DISRUPT MUSCARINIC SUPPRESSION OF CA2+ CURRENT AND M-CURRENT IN RAT SYMPATHETIC NEURONS [J].
BEECH, DJ ;
BERNHEIM, L ;
MATHIE, A ;
HILLE, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (02) :652-656
[8]   A DIFFUSIBLE 2ND MESSENGER MEDIATES ONE OF THE PATHWAYS COUPLING RECEPTORS TO CALCIUM CHANNELS IN RAT SYMPATHETIC NEURONS [J].
BERNHEIM, L ;
BEECH, DJ ;
HILLE, B .
NEURON, 1991, 6 (06) :859-867
[9]   CHARACTERIZATION OF MUSCARINIC RECEPTOR SUBTYPES INHIBITING CA2+ CURRENT AND M-CURRENT IN RAT SYMPATHETIC NEURONS [J].
BERNHEIM, L ;
MATHIE, A ;
HILLE, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (20) :9544-9548
[10]   INHIBITION OF CA-2+ AND K+ CHANNELS IN SYMPATHETIC NEURONS BY NEUROPEPTIDES AND OTHER GANGLIONIC TRANSMITTERS [J].
BLEY, KR ;
TSIEN, RW .
NEURON, 1990, 4 (03) :379-391