COORDINATION BEHAVIOR OF SULFATHIAZOLE - CRYSTAL-STRUCTURE OF [CU(SULFATHIAZOLE)(PY)(3)CL] SUPEROXIDE-DISMUTASE ACTIVITY

The preparation, spectroscopic, magnetic properties, and crystal structure of [Cu(stz)(py)(3)Cl] (stz(-) stands for the deprotonated form of sulfathiazole, 4-amino-N-2-thiazolylbencenosulfonamide) are reported. Crystals are orthorhombic, space group Pbca, with cell constants a=15.834(2), b= 17.512(4), and c=18.79(2) Angstrom, and Z=8. The structure was solved and refined to R=0.041 (R(w)=0.040). The structure consists of mononuclear units linked via hydrogen bonds to form the tridimensional pyramid. The geometry of CuN3N*NCl chromophore is distorted square-pyramid. The superoxide-dismutase mimetic activity of the compound is measured and compared with those of the SOD enzyme, the free drug, and other related sulfathiazole complexes.