EFFECTS OF SEMOTIADIL FUMARATE, A NOVEL CALCIUM-ANTAGONIST, ON BLOOD-PRESSURE AND HEART-RATE IN CONSCIOUS SPONTANEOUSLY HYPERTENSIVE RATS

被引：16

作者：

KANDA, A ^{[1
]}

HASHIMOTO, H ^{[1
]}

机构：

[1] DAIICHI PHARMACEUT CO LTD,TOKYO R&D CTR,EXPLORATORY RES LABS 2,16-13 KITA KASAI 1 CHOME,TOKYO 134,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1993年 / 63卷 / 01期

关键词：

SEMOTIADIL; ANTIHYPERTENSIVE EFFECT; SPONTANEOUSLY HYPERTENSIVE RAT;

D O I：

10.1254/jjp.63.121

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The acute antihypertensive effects of orally administered semotiadil, a novel calcium antagonist, were compared with those of nifedipine and diltiazem in conscious, unrestrained spontaneously hypertensive rats (SHRs). Semotiadil (10 and 30 mg/kg) produced a dose-dependent hypotension that persisted for 18 hr at 30 mg/kg. Diltiazem (30 and 100 mg/kg) and nifedipine (1 and 3 mg/kg) also exhibited hypotension dose-dependently, but their durations of actions were shorter than that of semotiadil. Semotiadil caused a slight increase in heart rate, while diltiazem and nifedipine caused a bradycardia and a marked tachycardia, respectively. These results suggest that semotiadil has a beneficial property as an antihypertensive drug.

引用

页码：121 / 124

页数：4

共 14 条

[1]

KAGEYAMA M, 1991, J CARDIOVASC PHARM, V17, P102, DOI 10.1097/00005344-199101000-00015

[2] ANTIHYPERTENSIVE EFFECT OF CV-4093.2HCL, A NEW CALCIUM-ANTAGONIST, IN 3 RAT MODELS OF HYPERTENSION [J].