SERUM LEVELS OF SOLUBLE CD4 AND CD8 MOLECULES IN HIV-INFECTION - EVALUATION OF LEVELS RELATIVE TO TREATMENT WITH ZIDOVUDINE

被引：0
|
作者：
PERRELLA, O [1 ]
CARRIERI, PB [1 ]
IZZO, E [1 ]
SOSCIA, E [1 ]
FICO, P [1 ]
CARUSO, I [1 ]
MORISCO, E [1 ]
LIBERTI, A [1 ]
GUARNACCIA, D [1 ]
CASTALDO, M [1 ]
机构：
[1] NAPLES UNIV,SCH MED 2,INST NEUROL,I-80138 NAPLES,ITALY
来源：
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 1991年 / 4卷 / 03期
关键词：
SOLUBLE CD4 MOLECULE; SOLUBLE CD8 MOLECULE; HUMAN IMMUNODEFICIENCY VIRUS; CD4+ LYMPHOCYTES; CD8+ LYMPHOCYTES; ZIDOVUDINE;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In the present study we investigated the levels of soluble CD4 (sCD4) and CD8 (sCD8) molecules in the serum of 45 patients, HIV-seropositive, classified as CDC III (PGL), before treatment and following zidovudine (ZVD) (600 mg/day) at 10 and 25 week intervals. A significant decrease of sCD4 (p < 0.05) and sCD8 (p < 0.05) molecules was observed in these patients after 10 weeks of ZVD therapy and this decrease was stable after 25 weeks. A statistically significant correlation was found between serological levels of both molecules and CD4+ and CD8+ cells. These findings suggest that sCD4 and sCD8 determinations could be a useful tool in monitoring long-term therapy ZVD and confirm a positive role of this drug on T lymphocyte activation in the course of HIV-infection.
引用
收藏
页码：181 / 186
页数：6
相关论文
共 50 条
  • [1] SERUM SOLUBLE CD4 AND CD8 LEVELS IN KAWASAKI-DISEASE
    FURUKAWA, S
    MATSUBARA, T
    TSUJI, K
    MOTOHASHI, T
    OKUMURA, K
    YABUTA, K
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1991, 86 (01): : 134 - 139
  • [2] SERUM-SOLUBLE CD4 AND CD8 LEVELS IN POLYMYALGIA-RHEUMATICA
    SALVARANI, C
    BOIARDI, L
    MACCHIONI, P
    MALDINI, MC
    MANCINI, R
    BELTRANDI, E
    ROSSI, F
    PORTIOLI, I
    JOURNAL OF RHEUMATOLOGY, 1994, 21 (10) : 1865 - 1869
  • [3] EVALUATION OF SERUM LEVELS OF SOLUBLE CD4, CD8 AND BETA(2)-MICROGLOBULIN IN VISCERAL HUMAN LEISHMANIASIS
    VITALE, G
    MOCCIARO, C
    MALTA, R
    GAMBINO, G
    SPINELLI, A
    GIORDANO, C
    STASSI, G
    ARCOLEO, F
    MILANO, S
    CILLARI, E
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1994, 97 (02): : 280 - 283
  • [4] SERUM LEVELS OF SOLUBLE CD4 AND CD8 IN PATIENTS WITH CHRONIC VIRAL-HEPATITIS
    ONJI, M
    DOI, Y
    MIYAOKA, H
    MASUMOTO, T
    HORIIKE, N
    OHTA, Y
    HEPATO-GASTROENTEROLOGY, 1994, 41 (04) : 377 - 379
  • [5] EXPRESSION OF CD28 ON CD8(+) AND CD4(+) LYMPHOCYTES DURING HIV-INFECTION
    CARUSO, A
    CANTALAMESSA, A
    LICENZIATI, S
    PERONI, L
    PRATI, E
    MARTINELLI, F
    CANARIS, AD
    FOLGHERA, S
    GORLA, R
    BALSARI, A
    CATTANEO, R
    TURANO, A
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1994, 40 (05) : 485 - 490
  • [6] CD4 AND CD8 T-CELLS WITH HIGH INTRACELLULAR GLUTATHIONE LEVELS ARE SELECTIVELY LOST AS THE HIV-INFECTION PROGRESSES
    ROEDERER, M
    STAAL, FJT
    OSADA, H
    HERZENBERG, LA
    HERZENBERG, LA
    INTERNATIONAL IMMUNOLOGY, 1991, 3 (11) : 1195 - &
  • [7] CD4 AND CD8 T-CELLS WITH HIGH INTRACELLULAR GLUTATHIONE LEVELS ARE SELECTIVELY LOST AS THE HIV-INFECTION PROGRESSES
    ROEDERER, M
    STAAL, FJT
    OSADA, H
    HERZENBERG, LA
    HERZENBERG, LA
    INTERNATIONAL IMMUNOLOGY, 1991, 3 (09) : 933 - 937
  • [8] SOLUBLE CD4/CD8 MOLECULES IN RHEUMATIC DISORDERS
    SAWADA, S
    TAKEI, M
    MITAMURA, K
    CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1994, 72 (02): : 177 - 180
  • [9] CYTOKINE DYSREGULATION IN CD4 AND CD8 T-CELLS IN HIV-INFECTION
    FAN, J
    BASS, H
    GUAN, WM
    FAHEY, JL
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1993, : 77 - 77
  • [10] INCREASED LEVELS OF SOLUBLE CD8 AND CD4 IN PATIENTS WITH INFECTIOUS-MONONUCLEOSIS
    YONEYAMA, A
    NAKAHARA, K
    HIGASHIHARA, M
    KUROKAWA, K
    BRITISH JOURNAL OF HAEMATOLOGY, 1995, 89 (01) : 47 - 54
12345