TREATMENT WITH INHALED STEROIDS IN ASTHMA AND CHRONIC-BRONCHITIS - LONG-TERM COMPLIANCE AND INHALER TECHNIQUE

被引：55

作者：

DOMPELING, E

VANGRUNSVEN, PM

VANSCHAYCK, CP

FOLGERING, H

MOLEMA, J

VANWEEL, C

机构：

[1] Department of Pulmonary Diseases, Nijmegen University

来源：

FAMILY PRACTICE | 1992年 / 9卷 / 02期

关键词：

D O I：

10.1093/fampra/9.2.161

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We investigated compliance and inhaler technique in 50 patients with airway obstruction (26 asthma, 24 chronic bronchitis) being treated with inhaled steroid (beclomethasone dipropionate, BDP) via a dry powder inhaler (Rotahaler(omega)). Patients had already participated for one year in a 2-year trial of BDP in general practice. They were treated daily with two dry powder inhalations of 400-mu-g BDP in combination with a bronchodilator. Compliance with BDP was measured by counting capsules (single-blind) at the end of a 4-month period and through a questionnaire. Counting capsules revealed non-compliance in 46% of the patients. Compliance was not related to age, sex, diagnosis or side-effects of BDP. In chronic bronchitis, but not in asthma, compliance was related to the outcome parameters of steroid treatment (pulmonary symptoms, change in lung function and non-specific bronchial responsiveness). The inhaler technique was judged insufficient in 27% of the patients. This study stresses the importance of regular instruction in inhaler technique and proper information about prophylactic steroid treatment by the general practitioner during the treatment of asthma and chronic bronchitis.

引用

页码：161 / 166

页数：6

共 34 条

[1]

Fletcher C., Peto R., Tinker C., Speizer F.E., The Natural History of Chronic Bronchitis and Emphysema., (1976)

[2]

Brown P.J., Greville H.W., Finucane K.E., Asthma and irre versible airflow obstruction, Thorax, 39, pp. 131-136, (1984)

[3]

Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma, Am Rev Respirdis, 136, pp. 225-243, (1987)

[4]

Barnes P.J., Effect of corticosteroids on airway hyper responsiveness, Am Rev Respirdis, 141, pp. s70-s76, (1990)

[5]

Svedmyr N., Action of corticosteroids on beta-adrenergic receptors. Clinical aspects, Am Rev Respir Dis, 141, pp. s31-s38, (1990)

[6]

Macklem P.T., A hypothesis linking bronchial hyperreactivity and airway inflammation: Implications for therapy, Ann Allergy, 64, pp. 113-116, (1990)

[7]

Ryan G., Latimer K.M., Juniper E.F., Roberts R.S., Hargreave F.E., Effect of beclomethasone dipropionate on bronchial responsiveness to histamine in controlled nonsteroid-dependent asthma, J Allergy Clin Immunol, 75, pp. 25-30, (1985)

[8]

Zuwallack R.L., Kass J., Shiue S., Et al., Effect of inhaled triamcinolone on bronchial hyperreactivity and airways obstruction in asthma, Ann Allergy, 64, pp. 207-212, (1990)

[9]

Li J., Reed C.E., Proper use of aerosol corticosteroids to control asthma, Mayo Din Proc, 64, pp. 205-210, (1989)

[10]

Berglund E., Inhalation therapy—problems and prospects, Eur Respir J, 3, pp. 830-832, (1990)

← 1 2 3 4 →