SUPEROXIDE-DEPENDENT FORMATION OF HYDROXYL RADICALS FROM FERRIC-COMPLEXES AND HYDROGEN-PEROXIDE - AN EVALUATION OF 14 IRON CHELATORS

被引：69

作者：

GUTTERIDGE, JMC ^{[1
]}

机构：

[1] OKLAHOMA MED RES FDN,OKLAHOMA CITY,OK 73104

来源：

FREE RADICAL RESEARCH COMMUNICATIONS | 1990年 / 9卷 / 02期

关键词：

EDTA; Fenton chemistry; Ferric complexes; Hydroxyl; NTA; Radical; SOD;

D O I：

10.3109/10715769009148579

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When a variety of ferric chelates are reacted with hydrogen peroxide in phosphate buffer deoxyribose is damaged and this damage is protected against by formate, thiourea and mannitol. Damage done by ferric complexes of citrate, EDTA, NTA, EGTA and HEDA is substantially inhibited by superoxide dismutase (SOD) whereas complexes of PLA. ADP and CDTA are moderately inhibited by SOD. The effects of SOD argue against hydrogen peroxide acting as a reductant in Fenton chemistry driven by ferric complexes and hydrogen peroxide. EDTA has proved to be a useful model for Fenton chemistry that is inhibited by SOD although, it is not unique in this respect. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：119 / 125

页数：7

共 21 条

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