INSITU HYBRIDIZATION AND TRANSLOCATION BREAKPOINT MAPPING .3. DIGEORGE SYNDROME WITH PARTIAL MONOSOMY OF CHROMOSOME-22

被引：28
作者：
CANNIZZARO, LA
EMANUEL, BS
机构：
[1] CHILDRENS HOSP, DEPT PEDIATR & HUMAN GENET, 34TH ST & CIVIC CTR BLVD, PHILADELPHIA, PA 19104 USA
[2] UNIV PENN, DEPT PEDIATR & HUMAN GENET, PHILADELPHIA, PA 19107 USA
来源：
CYTOGENETICS AND CELL GENETICS | 1985年 / 39卷 / 03期
关键词：
D O I：
10.1159/000132131
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We have performed in situ hybridization of a probe for the [human] .lambda. IGLC constant region to metaphase spreads from two DiGeorge syndrome (DGS)-related chromosomal rearrangements with breakpoints in 22q11. In this study we have demonstrated that the breakpoints are proximal to the .lambda. IGLC constant region cluster. Thus, at the molecular level, DGS-related breakpoints can be distinguished from the 22q11 breakpoint of CML, but not from the 8;22 translocation of Burkitt lymphoma or from the 21;22 translocations that we have previously studied.
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页码：179 / 183
页数：5
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