BIOSYNTHESIS OF AMINOCYCLITOL ANTIBIOTICS

被引：102
作者：
RINEHART, KL [1 ]
STROSHANE, RM [1 ]
机构：
[1] UNIV ILLINOIS ROGER ADAMS LAB, URBANA, IL 61801 USA
来源：
JOURNAL OF ANTIBIOTICS | 1976年 / 29卷 / 04期
关键词：
D O I：
10.7164/antibiotics.29.319
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A review on the biosynthesis of aminocyclitol antibiotics [by Streptomyces spp., Micromonospora spp. and Bacillus spp.] is presented. Little is certain about the order in which the subunits are joined, although it can be inferred from certain mutant studies that, at least in ribostamycin (and sisomicin) the order is neosamine C (or 2,6-diamino-2,3,4,6 tetradeoxy-D-glycero-hex-4-enose, dehydropurpurosamine) adding to deoxystreptamine, followed by addition of a 3rd unit. The enzymatic steps of bioconversion of glucose to the subunits of the aminocyclitol antibiotics are well understood only for the streptidine moiety of streptomycin. The intermediate compounds for the other subunits are only partially characterized.
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页码：319 / 353
页数：35
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