A NOVEL BROMOPYRROLE ALKALOID FROM THE SPONGE AGELAS-LONGISSIMA WITH ANTISEROTONERGIC ACTIVITY

被引：37
作者：
CAFIERI, F
FATTORUSSO, E
MANGONI, A
TAGLIALATELASCAFATI, O
CARNUCCIO, R
机构：
[1] DIPARTIMENTO CHIM SOSTANZE NAT, I-80131 NAPLES, ITALY
[2] DIPARTIMENTO FARMACOL SPERIMENTALE, I-80131 NAPLES, ITALY
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 08期
关键词：
D O I：
10.1016/0960-894X(95)00116-B
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Agelongine (1), a novel bromopyrrole alkaloid containing a pyridinium ring in place of the imidazole nucleus, usually found in Agelas alkaloids, has been isolated from the Caribbean sponge Agelas longissima, and its structure established by spectroscopic analysis and chemical degradation. Agelongine exhibited an antiserotonergic activity tested in vitro on the rat stomach fundus strip.
引用
收藏
页码：799 / 804
页数：6
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