NICKEL(III)-PROMOTED DNA CLEAVAGE WITH AMBIENT DIOXYGEN

被引：96

作者：

CHENG, CC ^{[1
]}

ROKITA, SE ^{[1
]}

BURROWS, CJ ^{[1
]}

机构：

[1] SUNY STONY BROOK,DEPT CHEM,STONY BROOK,NY 11794

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1993年 / 32卷 / 02期

关键词：

D O I：

10.1002/anie.199302771

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Oxygen-sensitive nickel(II) complexes with macrocyclic ligands promote DNA cleavage without additional oxidants, initiators, or irradiation. The reaction does not involve OH. radicals, but superoxido-Ni(III) complexes may play a role. The reactivity of the nickel complexes is highly dependent on the substituents on the ligands, which may allow fine-tuning for in vivo applications. R1,R2 e.g. F, H.

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页码：277 / 278

页数：2

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