T-CELL LARGE GRANULAR LYMPHOCYTIC-LEUKEMIA FOLLOWING ORTHOTOPIC LIVER-TRANSPLANTATION

被引：29

作者：

FEHER, O

BARILLA, D

LOCKER, J

OLIVERI, D

MELHEM, M

WINKELSTEIN, A

机构：

[1] UNIV PITTSBURGH,SCH MED,MED CTR,PITTSBURGH CANC INST,DEPT MED & PATHOL,PITTSBURGH,PA 15213

[2] INST TRANSFUS MED,PITTSBURGH,PA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1995年 / 49卷 / 03期

关键词：

T-CELL LARGE GRANULAR LYMPHOCYTIC LEUKEMIA; T-CELL RECEPTOR BETA-CHAIN; TAL-1; GENE;

D O I：

10.1002/ajh.2830490307

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aggressive T-cell neoplasms are an infrequent complication of allogeneic organ and bone marrow transplantation. To date, chronic T-cell lymphoproliferative malignancies have not been described. The present case documents the occurrence of a T-cell large granular lymphocytic leukemia (T-LGL) ina patient following orthotopic liver transplantation. Geno-type studies showed a clonal T-cell receptor beta-chain gene rearrangement. A unique feature was the detection of a specific chromosomal deletion at 1p32 involving the tal-1 gene, an abnormality previously described only in aggressive T-cell neoplasms. (C) 1995 Wiley-Liss, Inc.

引用

页码：216 / 220

页数：5

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