CARBAMAZEPINE-INDUCED THROMBOCYTOPENIA AND CARBAMAZEPINE-10,11-EPOXIDE - A CASE-REPORT

被引：6

作者：

KIMURA, M ^{[1
]}

YOSHINO, K ^{[1
]}

MAEOKA, Y ^{[1
]}

SUZUKI, N ^{[1
]}

机构：

[1] NATL NISHITOTTORI HOSP,DEPT PEDIAT,MITSU,TOTTORI,JAPAN

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 1995年 / 49卷 / 01期

关键词：

CARBAMAZEPINE; CARBAMAZEPINE-10,11-EPOXIDE; LYMPHOCYTE STIMULATION TEST; THROMBOCYTOPENIA;

D O I：

10.1111/j.1440-1819.1995.tb01860.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The case of a patient who developed thrombocytopenia during treatment with carbamazepine (CBZ) is described. The platelet count recovered soon after discontinuation of CBZ. Lymphocyte stimulation test with carbamazepine-10,11-epoxide (CBZ-10,11-EPOX), a major metabolite of CBZ, was positive, although with CBZ it was negative. These findings suggest that CBZ-10,11-EPOX was possibly causative in the pathogenesis of CBZ-induced thrombocytopenia in this case.

引用

页码：69 / 70

页数：2

共 13 条

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