AMYLOID PRECURSOR PROTEIN MESSENGER-RNA ENCODING THE KUNITZ PROTEASE INHIBITOR DOMAIN IS INCREASED BY KAINIC ACID-INDUCED SEIZURES IN RAT HIPPOCAMPUS

被引：34
|
作者：
WILLOUGHBY, DA
JOHNSON, SA
PASINETTI, GM
TOCCO, G
NAJM, I
BAUDRY, M
FINCH, CE
机构：
[1] UNIV SO CALIF,DEPT BIOL SCI,LOS ANGELES,CA 90089
[2] UNIV SO CALIF,PROGRAM NEUROSCI,LOS ANGELES,CA 90089
来源：
EXPERIMENTAL NEUROLOGY | 1992年 / 118卷 / 03期
关键词：
D O I：
10.1016/0014-4886(92)90191-R
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A 168-nucleotide exon, found in alternatively spliced amyloid precursor protein (APP) mRNAs, encodes a Kunitz protease inhibitor (KPI) domain. Kainic acid (ip) caused a selective increase of KPI mRNA in rat hippocampus. By in situ hybridization, KPI mRNA was induced in the neuronal layers of the hippocampus 11-12 h after the onset of kainate-induced seizures. The kainate-induced elevation of the KPI-containing APP-770 mRNA was blocked by pretreatment with the anticonvulsant pentobarbital. These data suggest that kainate-induced seizures cause alterations in APP RNA stability and/or processing in rat hippocampal neurons. © 1992.
引用
收藏
页码：332 / 339
页数：8
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