UNFAVORABLE OUTCOME OF A PATIENT WITH M2 ACUTE NONLYMPHOCYTIC LEUKEMIA AND A 47,XY,T(5-7)(Q34-Q21), +8 KARYOTYPE

被引：0

作者：

TESTONI, N

ZACCARIA, A

CELSO, B

TURA, S

机构：

来源：

HAEMATOLOGICA | 1991年 / 76卷 / 01期

关键词：

ACUTE NONLYMPHOCYTIC LEUKEMIA; (5-7) TRANSLOCATION;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a patient with M2 acute non-lymphocytic leukemia and a complex karyotype: 47,XY,t(5;7)(q34; q21), +8. After chemotherapy with Daunomycin and Arabinosyl Cytosine, a complete remission was reached, but two months later he relapsed and died because of sepsis. Only 5 other cases with translocations involving chromosomes 5 and 7 have been described, but with different breakpoints. Several genes related to cell proliferation and maturation have been identified on the long arms of chromosomes 5 and 7. The possible involvement of specific genes located at or very close to the breakpoints is hypothesized.

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页码：65 / 68

页数：4

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