UNFAVORABLE OUTCOME OF A PATIENT WITH M2 ACUTE NONLYMPHOCYTIC LEUKEMIA AND A 47,XY,T(5-7)(Q34-Q21), +8 KARYOTYPE

被引：0
作者：
TESTONI, N
ZACCARIA, A
CELSO, B
TURA, S
机构：
来源：
HAEMATOLOGICA | 1991年 / 76卷 / 01期
关键词：
ACUTE NONLYMPHOCYTIC LEUKEMIA; (5-7) TRANSLOCATION;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report a patient with M2 acute non-lymphocytic leukemia and a complex karyotype: 47,XY,t(5;7)(q34; q21), +8. After chemotherapy with Daunomycin and Arabinosyl Cytosine, a complete remission was reached, but two months later he relapsed and died because of sepsis. Only 5 other cases with translocations involving chromosomes 5 and 7 have been described, but with different breakpoints. Several genes related to cell proliferation and maturation have been identified on the long arms of chromosomes 5 and 7. The possible involvement of specific genes located at or very close to the breakpoints is hypothesized.
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页码：65 / 68
页数：4
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