ANTITUMOUR AGENTS SYNTHESIZED FROM K2PTCL4 AND POLYMERIC OR CYCLIC PHOSPHAZENES

被引：25

作者：

ALLCOCK, HR ^{[1
]}

ALLEN, RW ^{[1
]}

OBRIEN, JP ^{[1
]}

机构：

[1] PENN STATE UNIV, DEPT CHEM, UNIVERSITY PK, PA 16802 USA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1976年 / 18期

关键词：

D O I：

10.1039/c39760000717

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The phosphazenes [NP(NHMe)2]n, [NP(NHMe)2]4 and [NPMe2]4, react with K2PtCl4 [dipotassium platinum tetrachloride] in organic media to yield square planar Pt complexes of the type, (NPR2)x-PtCl2 and in aqueous acid media to yield salts of the type, [H2N4P4R8]2+[PtCl4]2-. These compounds showed significant antitumor behavior in preliminary testing in P388 mouse leukemia.

引用

页码：717 / 718

页数：2